Cholesterol-tethered platinum II-based supramolecular nanoparticle increases antitumor efficacy and reduces nephrotoxicity

By Researchers at Brigham and Women’s Hospital (BWH)  Cambridge.

They  are the first to report a new approach that integrates rational drug design with supramolecular nanochemistry in cancer treatment. Nanoscale drug delivery vehicles have been harnessed extensively as carriers for cancer chemotherapeutics. However, traditional pharmaceutical approaches for nanoformulation have been a challenge with molecules that exhibit incompatible physicochemical properties, such as platinum-based chemotherapeutics…